Since 1996, over $257,000 has been provided for clinical research projects focusing on a broad range of pediatric and adult chronic lung problems. This area of funding adddresses our secondary mission of support for medically underserved individuals with chronic respiratory problems. Research studies are usually conducted by fellows and faculty of the Division of Pulmonary and Critical Care Medicine and the Division of Pediatric Pulmonary Medicine at the University of Washington in Seattle. Grants range, on average, from $5000 to $20,000. Results of these studies are often presented at international meetings such as the American Thoracic Society and published in refereed journals.
The following list of funded studies is included here to illustrate the typical scope and magnitude of such studies.
Exhaled Nitric oxide in infants during and following respiratory syncytial virus bronchiolitis. Danny Hsia, MD; Pediatric Pulmonary Medicine, Children’s Hospital and Regional Medical Center, $19,950, 2006
Asthma and diesel exhaust exposure: understanding the relationship. Joel Kaufman MD, MPH, Chris Carlsten, MD, Teal Hallstrand MD, Terry Kavanagh, PhD; Environmental and Occupational Health, University of Washington, $13,285, 2006
The Effects of exercise, forced exhalation and bronchoconstriction on respiratory solute concentration in exhaled breath condensate. Teal Hallstrand, MD MPH; Pulmonary Division, University of Washington, $19,093; 2005
Anemia and COPD: Prevalence and Clinical Outcomes. Erik Swenson, MD and David Au, MD; Seattle Institute for Biomedical and Clinical Research, VA Puget Sound Health Care System; Pulmonary Division, University of Washington, $8000; 2005
Assessment of functional recovery after acute lung injury, Catherine Lee, MD, MSc, Leonard Hudson, MD, Division of Pulmonary and Critical Care Medicine, University of Washington; $7,000; 2004
Measurement of cysteinyl leukotrienes in exhaled breath condensate in children pre and post extubation. Jason Debley, MD; Pediatric Pulmonary Medicine, Children’s Hospital and Regional Medical Center, $14,734; 2004
COPD and hazardous drinking: health behaviors and resource utilization. Laura Evans, MD, and David Au, MD MS, Health Services Research and Development, VA Medical Center; Pulmonary Division, University of Washington; $17,000; 2004
Measurement of exhaled nitric oxide in infants and toddlers via a tidal breathing method: a pilot study. Jason Debley, MD; Pediatric Pulmonary Medicine, Children’s Hospital and Regional Medical Center; $20,075; 2002
Accuracy of end-tidal carbon dioxide measurement in predicting arterial carbon dioxide levels in patients with neuromuscular disease. Louis Boitano, MS RRT, Joshua Benditt, MD, Janet King, MD; University of Washington Medical Center, $4,990; 2002
Ibuprofen oral provocation challenge in asthmatic children. Jason Debley, MD; Pediatric Pulmonary Medicine, Children’s Hospital and Regional Medical Center, $22,046; 2001
Improving the quality of physician/patient communication for non-English speaking patients with COPD. Randall Curtis, MD; Division of Pulmonary and Critical Care Medicine; Harborview Medical center and University of Washington; $24,000; 2001
A randomized double-blind placebo-controlled trial of oral corticosteroid therapy in cystic fibrosis patients hospitalized for pulmonary exacerbation. Mark Dovey MD, Moira Aitken, MD, Julia Emerson MD MPH, Ronald Gibson MD,. Sharon McNamara MN RN; Pediatric Pulmonary Medicine, Children’s Hospital and Regional Medical Center; $20,000; 2000
Validation of sputum induction (SI) as a research tool for lower airway sampling in patients with cystic fibrosis. Moira Aitken, MD; Division of Pulmonary and Critical Care Medicine, University of Washington; $10,442, 2000 (paper published in Thorax 2001; 56:306-311)
King County Lung Injury project (data extraction for a study looking at management of ARDS in community hospitals); Gordon Rubenfeld, MD; Division of Pulmonary and Critical Care Medicine, University of Washington; $20,188; 1999
Epidemiological studies in cystic fibrosis: survival of women with CF who become pregnant; effect of Stenotrophomonas maltophilia colonization in patients with CF. Christopher Goss, MD, Gordon Rubenfeld, MD; Division of Pulmonary and Critical Care Medicine, University of Washington; $7151, 1999
The role of inflammatory mediators in exercise-induced asthma, Teal Hallstrand, MD, Moira Aitken, MD; Division of Pulmonary and Critical Care Medicine, University of Washington; $14,507, 1999
Quality of life in interstitial lung disease. Jacqueline Chang, MD, Ganesh Raghu, MD; Division of Pulmonary and Critical Care Medicine, University of Washington; $7,673; 1998 (abstract presented at ATS)
Efficacy of sputum induction as a tool for assessing airways inflammation in cystic fibrosis. Noreen Henig, MD, Moira Aitken, MD; Division of Pulmonary and Critical Care Medicine, University of Washington; $7,049; 1999