Since 1996, over $257,000 has been awarded for clinical research projects focusing on a broad range of pediatric and adult chronic lung problems. This area of funding adddresses our secondary mission of support for medically underserved individuals with chronic respiratory problems. Research studies are usually conducted by fellows and faculty of the Division of Pulmonary and Critical Care Medicine and the Division of Pediatric Pulmonary Medicine at the University of Washington in Seattle. Grants range, on average, from $5000 to $20,000. Results of these studies are often presented at international meetings such as the American Thoracic Society and published in refereed journals. The following list of selected studies illustrate the typical scope of funded studies.
TB Research
2006-2009
The role of toll-like receptor-2 (TLR-2) in production of the CD8 T-cells regulator, IL-15, in response to Mycobacterium bovis (BCG) and Mycobacterium tuberculosis. Shawn J Skerrett, MD, Amy Bryant, PhD, Dennis Stevens MD PhD, Tanyalak Parimon, MD. Pulmonary Division, University of Washington; $14,059
2000-2005
Regional Tuberculosis Strain Genotyping Service at Seattle Biomedical Research Institute. Leonard Hudson, MD, Jerry Cangelosi, PhD, and Kathleen Horan, MD; Pulmonary Division, University of Washington; $10,019
Dual block PCR thermocycler for Seattle Biomedical Research Institute’s TB Strain Genotyping service; (equipment to help identify TB strains) Gerard Cangelosi, PhD; $7,490
Analysis software for Seattle Biomedical Research Institute’s TB Strain Genotyping service; Gerard Cangelosi, PhD; $12,500
Equipment for the BL3 tuberculosis containment laboratory at Harborview Medical Center. David Park, MD; Division of Pulmonary and Critical Care Medicine, University of Washington; $27,502
Clinical Research in Chronic Lung Diseases
2006-2009
Exhaled Nitric oxide in infants during and following respiratory syncytial virus bronchiolitis. Danny Hsia, MD; Pediatric Pulmonary Medicine, Children’s Hospital and Regional Medical Center, $19,950
Asthma and diesel exhaust exposure: understanding the relationship. Joel Kaufman MD, MPH, Chris Carlsten, MD, Teal Hallstrand MD, Terry Kavanagh, PhD; Environmental and Occupational Health, University of Washington, $13,285
2000-2005
The Effects of exercise, forced exhalation and bronchoconstriction on respiratory solute concentration in exhaled breath condensate. Teal Hallstrand, MD MPH; Pulmonary Division, University of Washington, $19,093
Anemia and COPD: Prevalence and Clinical Outcomes. Erik Swenson, MD and David Au, MD; Seattle Institute for Biomedical and Clinical Research, VA Puget Sound Health Care System; Pulmonary Division, University of Washington, $8000
Assessment of functional recovery after acute lung injury, Catherine Lee, MD, MSc, Leonard Hudson, MD, Division of Pulmonary and Critical Care Medicine, University of Washington; $7,000
COPD and hazardous drinking: health behaviors and resource utilization. Laura Evans, MD, and David Au, MD MS, Health Services Research and Development, VA Medical Center; Pulmonary Division, University of Washington; $17,000
Measurement of exhaled nitric oxide in infants and toddlers via a tidal breathing method: a pilot study. Jason Debley, MD; Pediatric Pulmonary Medicine, Children’s Hospital and Regional Medical Center; $20,075
Ibuprofen oral provocation challenge in asthmatic children. Jason Debley, MD; Pediatric Pulmonary Medicine, Children’s Hospital and Regional Medical Center, $22,046
Improving the quality of physician/patient communication for non-English speaking patients with COPD. Randall Curtis, MD; Division of Pulmonary and Critical Care Medicine; Harborview Medical center and University of Washington; $24,000